Research Infrastructure Programs Grants (Assistance Listing 93.351)

National Institutes of Health · Amount varies

This NIH STTR program (R41/R42) funds U.S. small businesses that partner with a nonprofit research institution to move scientific innovations toward commercialization. Eligibility is limited to U.S. small business concerns as defined by the SBA, and foreign organizations are not eligible. No award amount is listed.

National Institutes of Health · Amount varies

This NIH SBIR Phase IIB award is restricted to U.S. small business concerns that have previously received an NIH SBIR or STTR Phase II award; it bridges the gap between Phase II and commercialization for later-stage R&D. Only one such award is allowed per project, and applications must be submitted within the first six due dates after the Phase II budget period ends, so it is narrow and limited to existing grantees. Foreign organizations are not eligible to apply.

National Institutes of Health · Amount varies

This NIH SBIR/STTR Commercialization Readiness Pilot (CRP) is restricted to U.S. small business concerns (as defined by the SBA) and helps move NIH-funded SBIR/STTR projects from late-stage development toward commercialization. It supports later-stage R&D and technical assistance such as replication studies, IND/IDE-enabling work, clinical studies, manufacturing scale-up, and regulatory support, and a significant portion may be subcontracted. Foreign organizations are not eligible to apply.

National Institutes of Health · Amount varies

This NIH/CDC/FDA SBIR program (R43/R44) funds U.S. small businesses developing scientific innovations toward commercial products through feasibility and R&D studies. Eligibility is limited to U.S. small business concerns as defined by the SBA, and foreign organizations are not eligible. No award amount is listed.

National Institutes of Health · $25K–$250K

This NIH S10 instrumentation grant funds resource-limited institutions to purchase state-of-the-art scientific instruments supporting biomedical research and education. It is a limited competition that invites applications only from eligible organizations, and awards range from about $25,000 to $250,000. Foreign organizations and foreign components of U.S. organizations are not eligible to apply.

National Institutes of Health · Up to $500K

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R01 funds groundbreaking, high-impact Down syndrome research across any relevant topic, with no preliminary data required. Awards up to about $500,000.

National Institutes of Health · Up to $200K

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R21 funds exploratory, higher-risk Down syndrome research — feasibility studies, novel methods, or new applications of existing techniques. Awards up to about $200,000.

National Institutes of Health · Amount varies

This NIH/ORIP R24 grant funds research organizations to develop, characterize, or improve models of human health and disease (including new approach methodologies) that are broadly useful across two or more NIH Institutes. Projects narrowly tied to a single disease or to one Institute's interests will not be accepted. Foreign organizations, foreign components of U.S. organizations, and foreign components are not eligible or allowed.

National Institutes of Health · Amount varies

This NIH/ORIP P40 grant funds Animal and Biological Material Resource Centers that maintain specialized animal colonies, cell and tissue cultures, genetic stocks, and related services for the biomedical research community. Proposed centers must have broad relevance across multiple NIH Institutes. Foreign organizations and foreign components of U.S. organizations are not eligible to apply, and foreign components are not allowed.

National Institutes of Health · Amount varies

This NIH opportunity provides administrative supplements only to organizations that already hold an active, eligible NIH grant or cooperative agreement, to cover unforeseen increased costs within the scope of the existing project. New applicants without a current NIH award cannot use it. Funding is not guaranteed, and applicants must discuss requests with the awarding Institute's staff before submitting; foreign organizations may apply only consistent with the existing parent award.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R01 supports early-stage investigators pursuing a new research direction, and applications must include no preliminary data. Award size follows standard R01 limits; aimed at researchers early in their independent careers.

National Institutes of Health · Amount varies

Open to domestic institutions — universities, research institutions, nonprofits, and certain government/tribal organizations (foreign institutions are not eligible). This NIH T35 funds short-term (often summer) research-training experiences for health-professional and graduate students. It supports the institution's training program rather than an individual.

National Institutes of Health · Amount varies

The NIH parent Research Project Grant (R01, clinical trial not allowed) supports investigator-initiated research projects aligned with participating NIH institutes' missions, excluding clinical trials. A broad range of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. No specific award amount is stated. This is a core NIH research mechanism aimed at research institutions.

National Institutes of Health · Up to $375K

The REAP program funds small-scale research at health professional and graduate schools that haven't been major recipients of NIH support, while giving students hands-on research experience. Eligibility is limited to institutions awarding NIH-relevant degrees that received under $6 million per year in NIH support in 4 of the last 7 years — a specific financial threshold worth checking before applying. Awards go up to $375,000.

National Institutes of Health · Up to $200K

This NIH ORIP (R21) opportunity funds research to develop, improve, and preserve animal models and related biological materials with broad applicability across multiple NIH institutes; single-disease or single-institute projects are out of scope. It is aimed at research and academic institutions; foreign organizations are not eligible. The maximum award is about $200,000.

National Institutes of Health · Amount varies

This NIH training grant funds domestic institutions of higher education (including HBCUs, Hispanic-serving institutions, and tribal colleges) to build predoctoral and postdoctoral biomedical research training programs, not individual researchers directly. Eligibility is fairly broad among institution types, but non-domestic entities and their foreign components are excluded, and the program does not support short-term-only training plans. No dollar amount is listed, and the deadline is not near-term.

National Institutes of Health · Amount varies

An NIH research project grant (R01, clinical trial not allowed) supporting screening and functional validation of genomic variants linked to human congenital anomalies, developmental disabilities, and inborn errors of metabolism. A broad set of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. No specific award amount is stated. This is a basic-science genomics mechanism for research institutions.

National Institutes of Health · Amount varies

This NIH High-End Instrumentation (HEI) program funds groups of NIH-supported investigators to purchase or upgrade a single piece of high-end research instrumentation, with awards ranging from a minimum of $750,001 up to $2,000,000. Eligible applicants are U.S. research institutions, including minority-serving institutions and tribally controlled colleges; foreign organizations and their components are not eligible and foreign components are not allowed. Note a key restriction: applicants must have groups of existing NIH-supported investigators, so this is not for individuals, new organizations, or general nonprofits. This is a large-award instrumentation grant for established research institutions.

National Institutes of Health · Amount varies

This NIH Basic Instrumentation Grant (BIG) program funds groups of NIH-supported investigators to purchase a single specialized research instrument, with awards from $25,000 up to $350,000. Eligibility is limited to U.S. institutions that have not received $500,001 or more in S10 instrumentation funding in the preceding three fiscal years; foreign organizations and their components are not eligible and foreign components are not allowed. It requires groups of existing NIH-supported investigators, so it is not for individuals, new organizations, or general nonprofits. This is an instrumentation grant for less-funded research institutions.

National Institutes of Health · Amount varies

This NIH Shared Instrumentation Grant (SIG) program funds groups of NIH-supported investigators to purchase or upgrade a single specialized research instrument, with awards from $50,000 up to $750,000. Eligible applicants are U.S. research institutions, including minority-serving and tribally controlled colleges; foreign organizations and their components are not eligible and foreign components are not allowed. It requires groups of existing NIH-supported investigators, so it is not for individuals, new organizations, or general nonprofits. This is a large-award instrumentation grant for established research institutions.

National Institutes of Health · Up to $350K

This NIH program (S15) helps eligible academic or research institutions buy modern equipment to modernize shared-use biomedical research facilities such as core labs and animal research facilities. Eligible applicants are institutions, including minority-serving institutions, HBCUs, and tribal colleges; foreign organizations and foreign components are not eligible. The award ceiling is about $350,000, and the program does not fund scientific research instruments themselves or building-level infrastructure. This is institution-focused support, not for individuals or general organizations.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific NIH grants and need to transfer an award due to a change in organizational status (successor-in-interest). It is an administrative prior-approval request, not a new funding opportunity, and approval of the transfer is not guaranteed. Only current NIH grantee organizations should use it; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific types of NIH grants and need to transfer an existing award to a new recipient institution (a change of recipient organization). It is an administrative prior-approval request, not a new funding opportunity, and there is no guarantee a transfer will be approved. Only current NIH grantee organizations should apply; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH mentored research scientist award (K01) provides three to five years of protected, supervised career development leading to research independence; this version does not allow leading an independent clinical trial. It is intended for individual investigators applying through eligible institutions such as universities. No award amount is listed.

National Institutes of Health · Amount varies

This NIH/ORIP resource award (R24) funds core facilities, resource centers, animal vivaria, or investigators to acquire equipment and study how environmental extrinsic factors affect animal research, aiming to improve rigor and reproducibility. The work must be broadly relevant to two or more NIH Institutes or Centers. Eligible applicants are institutions, including minority-serving institutions, HBCUs, and tribal colleges; foreign organizations and foreign components of U.S. organizations are not eligible to apply, though foreign components are otherwise allowed. No award amount is stated; eligibility centers on research institutions and shared-resource facilities.

National Institutes of Health · Amount varies

This NIH limited-competition program (U42) provides continuing support for specific pathogen-free macaque breeding colonies that supply animals for HIV/AIDS research, building on prior awards. Because it is a limited competition continuing previously funded colonies, eligibility is narrow; foreign organizations and foreign components of U.S. organizations are not eligible, and applicants should see the NOFO for details. No award amount is stated. This is effectively restricted to organizations operating the relevant macaque colonies, not open to general applicants.

National Institutes of Health · Amount varies

This NIH limited-competition program (P51) supports the activities of the National Primate Research Centers, which provide nonhuman primate resources to investigators nationally. Because it is a limited competition tied to the existing primate centers, eligibility is narrow; foreign institutions and foreign components are not eligible to apply, and applicants should consult the full announcement for eligibility details. No award amount is stated. This is effectively restricted to organizations operating designated primate research centers, not open to general applicants.