Grants for Nonprofits

Dept of the Army -- Materiel Command · Amount varies

A U.S. Army (West Point / U.S. Military Academy) Broad Agency Announcement soliciting basic and applied research and analysis across science, engineering, education, policy, ethics, history, and economics. Eligibility is broad, including higher-education institutions, nonprofits, state and local governments, for-profit organizations (large and small businesses), and foreign organizations/public entities, with no restriction on place of performance. No award amount is specified, and funding depends on the specific proposal. Proposals must advance the state of the art or basic knowledge rather than target specific devices.

U.S. National Science Foundation · Amount varies

This NSF EPSCoR program funds research fellowships that build research capacity for investigators in EPSCoR-eligible jurisdictions through collaborative visits to host institutions. Eligibility is restricted to organizations located in RII-eligible jurisdictions, and proposals are limited to single early- or mid-career PIs at eligible institutions of higher education or non-degree-granting nonprofits with 501(c)(3) status; postdocs in transitional appointments are not eligible. No award amount is listed.

U.S. National Science Foundation · Amount varies

This NSF program funds open-science work such as research data management, cyberinfrastructure, and scientific publication models that make research data findable, accessible, interoperable, and reusable. Eligibility is limited to U.S. institutions of higher education, non-profit non-academic research organizations, federally recognized tribal nations, and certain federal agencies and FFRDCs. No award amount is listed.

Dept of the Army -- Materiel Command · Amount varies

This U.S. Army Research Office broad agency announcement funds collaborative research and fellowships in quantum computing and qubit development through the LPS Qubit Collaboratory. Eligibility is broad, including individuals, universities, nonprofits, small businesses, other for-profits, and FFRDCs, with collaboration alongside a government laboratory. No award amount is listed.

U.S. National Science Foundation · Amount varies

This NSF solicitation funds Antarctic research that requires logistical fieldwork support from the U.S. Antarctic Program (USAP), spanning Earth systems, biological, geochemical, and physical sciences. Eligible applicants are limited to U.S.-based non-profit non-academic research organizations (such as museums, observatories, and research laboratories), accredited U.S. institutions of higher education, and federally recognized tribal nations; individuals and businesses are not among the listed eligible submitters. Available USAP logistical support is currently limited due to facility maintenance, so applicants should follow the solicitation's guidance. Award amounts are not specified.

Department of Housing and Urban Development · $0

This HUD notice of intent previews a future opportunity inviting unsolicited research proposals on housing and community development priorities such as affordability, homelessness, and housing stability. Eligible applicants are philanthropic entities (including 501(c)(3) foundations and public charities), other federal agencies, state or local governments, Indian tribes, tribally-designated housing entities, and colleges or universities; individuals, foreign entities, and sole proprietorships are not eligible, and no profit may be earned. Note a significant disqualifier: projects must include matching funds equal to at least 50 percent of total project cost. Award amounts are not specified in the notice.

DOT - FAA Aviation Research Grants · $0–$6M

This FAA program funds aviation research grants and cooperative agreements supporting civil aviation and commercial space transportation, across topics like air traffic technology, aviation safety, weather, airports, and human factors, with awards up to about $6 million. Eligible applicants are public and state-controlled institutions of higher education, private institutions of higher education, and 501(c)(3) nonprofit research institutions other than higher-education institutions. It is not open to individuals or businesses, and applicant eligibility can vary with the nature of the research proposed. This is a large-award program aimed at universities and nonprofit research organizations.

National Institutes of Health · Amount varies

This NIH (R13) program supports conferences and scientific meetings relevant to public health and the missions of participating NIH institutes. Eligible applicants are U.S. research and education organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Note that R13 conference support typically requires advance permission from the funding institute before applying. It is aimed at organizations hosting scientific conferences, not individuals. Award amounts are not specified.

Bureau of Reclamation · $50K–$3M

This Bureau of Reclamation program funds water resource projects such as conservation and efficiency, infrastructure improvements, and watershed restoration, with awards from about $50,000 up to $3 million. Eligible applicants are states, tribes, irrigation and water districts, water/power authorities, certain nonprofit conservation organizations partnering with those entities, and qualifying watershed groups; applicants generally must be in the Western U.S. or named territories. Federal entities, individuals, and institutions of higher education are not eligible, and projects require a cost share (typically 25-50 percent of total cost). This is a geographically restricted opportunity aimed at water-management organizations.

Defense Health Agency Contracting Activity - DHACA · Amount varies

This Department of Defense (DHAPP/PEPFAR) program funds HIV/AIDS prevention, care, and treatment interventions delivered through the military health systems of foreign countries. Eligibility is described as unrestricted (open to any type of entity), subject to clarification in the announcement, but the work is inherently international and country-specific, so it suits organizations capable of working with foreign militaries. The announcement is revised regularly with country-specific narratives, and award amounts are not specified. Review the full announcement and its country attachments to confirm eligibility and scope.

Air Force -- Research Lab · Amount varies

This Air Force Research Laboratory opportunity (CHEERS) solicits white papers, and potentially later technical and cost proposals, on human performance research areas defined in attached statements of objectives. Eligibility is described as unrestricted (open to any type of entity), subject to clarification in the full announcement, so a range of organizations including businesses, nonprofits, and universities may be able to apply. Applicants must reference the related Multiple Authority Announcement to obtain required attachments. Award amounts are not specified, and specific eligibility terms are somewhat vague, so review the full solicitation carefully.

Defense Health Agency Contracting Activity - DHACA · Amount varies

This Defense Health Agency broad agency announcement (BAA) solicits extramural basic and applied medical research and development proposals that benefit both military and civilian medical practice. Eligibility is unrestricted, meaning any type of entity may apply, subject to clarifications in the notice. No award amount is specified. The selection process is highly competitive, and projects must focus on advancing scientific knowledge rather than developing a specific system or product.

Air Force -- Research Lab · Amount varies

This Air Force Research Laboratory solicitation (CHEERS) seeks white papers, and potentially later proposals, on human-effectiveness and aerospace-medicine research for experimental and test purposes in defense development. Eligibility is unrestricted, meaning any type of entity may apply, subject to clarifications in the notice. No award amount is specified. Applicants must reference the related Multiple Authority Announcement to obtain required attachments, and the work is tied to specific defense research objectives.

National Institutes of Health · Amount varies

This NIH/NINDS U01 funds IND-enabling studies and planning for first-in-human testing of gene-based therapies for ultra-rare neurological and neuromuscular disorders. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; foreign organizations are not eligible, and it targets research organizations rather than individuals. No award amount is specified. The ultra-rare gene-therapy focus makes eligibility narrow.

National Institutes of Health · Amount varies

This NIH/NCI U01 funds cancer etiology and early-detection biomarker research that must use the NCI-sponsored PLCO Screening Trial biospecimen resource. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it targets research organizations, not individuals. No award amount is specified. Projects that do not use PLCO biospecimens will not be funded, which narrows eligibility significantly.

National Institutes of Health · Up to $500K

This NIH/NIDCD R01 funds translational research that turns basic findings into clinical tools for communication disorders such as hearing, balance, voice, speech, and language. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations, not individuals. Awards reach up to about $500,000. Projects must show a clear clinical connection and practical impact, so the scope is specific.

National Institutes of Health · Amount varies

This NIH/NIMH R01 funds confirmatory efficacy clinical trials of non-pharmacological and pharmacological interventions for mental disorders in adults and children, with a clinical trial required. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations rather than individuals. No award amount is specified. Trials must follow NIMH's experimental-therapeutics design, so the scope is narrow.

National Institutes of Health · Amount varies

This NIH/NIMH R01 funds full-scale hybrid effectiveness-implementation clinical trials of mental health treatment, prevention, or services interventions in community and practice settings, with a clinical trial required. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations rather than individuals. No award amount is specified. Trials must be well-powered and follow NIMH's experimental-therapeutics approach, so the scope is specific.

National Institutes of Health · Amount varies

This NIH/NIMH R01 funds pilot effectiveness trials of mental health treatment, prevention, and services interventions, with a clinical trial required. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations rather than individuals. No award amount is specified. Studies must follow NIMH's experimental-therapeutics approach, so the scope is specific.

National Institutes of Health · Amount varies

This NIH/NIMH award (R61/R33) funds feasibility work followed by clinical trials testing mental-health system interventions to improve the organization, delivery, and outcomes of mental health services. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations rather than individuals. No award amount is specified. The focus on system-level interventions and required clinical trial make the scope narrow.