Research and Training in Complementary and Integrative Health Grants (Assistance Listing 93.213)

National Institutes of Health · Amount varies

This NIH HEAL Initiative UG3/UH3 cooperative agreement funds preclinical optimization and development of safe, non-addictive small-molecule and biologic therapeutics for treating pain, advancing candidates toward Phase II trials. Applicants must already have a promising lead candidate, a strong biological rationale, and established assays. Foreign organizations and foreign components of U.S. organizations are not eligible to apply.

National Institutes of Health · Amount varies

This NIH Predoctoral-to-Postdoctoral Transition Award (F99/K00) supports promising graduate students as they finish doctoral research and move into mentored postdoctoral career development, in NIH mission-relevant fields. It is a mentored training award administered through institutions; candidates may not lead an independent clinical trial but may participate in a sponsor-led one. Only domestic U.S. organizations may apply; foreign organizations are not eligible, though foreign components are allowed.

National Institutes of Health · Amount varies

This NIH HEAL Initiative R61/R33 grant funds action-oriented research that translates addiction epidemiology, prevention, treatment, and recovery findings into practice to address the opioid crisis and overdose. Projects can target individual, provider, organizational, community, or system levels. Foreign organizations and foreign components of U.S. organizations are not eligible to apply, though foreign components within a project may be allowed.

National Institutes of Health · Amount varies

This NIH STTR program (R41/R42) funds U.S. small businesses that partner with a nonprofit research institution to move scientific innovations toward commercialization. Eligibility is limited to U.S. small business concerns as defined by the SBA, and foreign organizations are not eligible. No award amount is listed.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative U01 funds development of scalable technologies to map brain connectivity across scales in humans, non-human primates, and mice, feeding into the BRAIN CONNECTS network; no clinical trial is allowed. Eligibility is described in the funding notice, and foreign organizations and their U.S. components may apply. No award amount is specified. Funded projects must integrate into a coordinated network, so review the notice's eligibility details carefully.

National Institutes of Health · Amount varies

This NIH/CDC/FDA SBIR program (R43/R44) funds U.S. small businesses developing scientific innovations toward commercial products through feasibility and R&D studies. Eligibility is limited to U.S. small business concerns as defined by the SBA, and foreign organizations are not eligible. No award amount is listed.

National Institutes of Health · Amount varies

The NIH Science Education Partnership Award (SEPA, R25) funds educational projects that increase understanding of biomedical research among pre-college (pre-K through grade 12) students and encourage interest in STEM careers. It suits universities, research institutions, and education-focused organizations that can run science education programs. Only domestic U.S. organizations may apply; foreign organizations are not eligible and foreign components are not allowed. Clinical trials are not permitted.

National Institutes of Health · Up to $700K

An NIH BRAIN Initiative R61 funding exploratory human neuroscience using invasive neural recording and stimulation during surgical procedures. Foreign organizations and foreign components are not eligible; the work requires multidisciplinary teams with access to neurosurgical settings. Awards reach up to about $700,000, and clinical trials are not allowed. This is a highly specialized research award for institutions with relevant clinical/research capacity, not for general nonprofits, small businesses, or individuals.

National Institutes of Health · Amount varies

This NIH opportunity provides administrative supplements only to organizations that already hold an active, eligible NIH grant or cooperative agreement, to cover unforeseen increased costs within the scope of the existing project. New applicants without a current NIH award cannot use it. Funding is not guaranteed, and applicants must discuss requests with the awarding Institute's staff before submitting; foreign organizations may apply only consistent with the existing parent award.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R61/R33 funds mechanistic clinical research on how mind-and-body interventions (e.g., meditation, yoga, acupuncture) affect emotional well-being and whole-person health, in two milestone-tied phases. Strong preliminary data are expected.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative R01 funds development of computational theories, models, and methods for analyzing complex brain-circuit data, to be shared with the research community. Eligible applicants are research organizations, including faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it targets institutions rather than individuals. No award amount is specified. The work is narrowly scoped to neural-circuit tool building, so confirm fit before applying.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R01 supports early-stage investigators pursuing a new research direction, and applications must include no preliminary data. Award size follows standard R01 limits; aimed at researchers early in their independent careers.

National Institutes of Health · Amount varies

This NIH program (Blueprint MedTech Translator) funds translational research and clinical feasibility studies for therapeutic and diagnostic devices targeting nervous- or neuromuscular-system disorders, open to a broad range of institutions including HBCUs, Hispanic-serving institutions, tribal colleges, faith- and community-based organizations, and individuals or businesses developing their own devices. It is a milestone-driven cooperative agreement requiring NIH staff involvement in project planning and monitoring. No award amount is specified, and the deadline is not imminent.

National Institutes of Health · Amount varies

This NIH fellowship supports predoctoral students pursuing a combined MD/PhD or similar dual-doctoral degree at institutions that lack an NIH-funded dual-degree training program, aiming to prepare them for physician-scientist careers. It applies to individual students, not organizations, and excludes foreign organizations and their non-U.S. components; applicants cannot lead an independent clinical trial. No funding amount is given, and the deadline is not imminent.

National Institutes of Health · Amount varies

This NIH fellowship funds individual postdoctoral researchers who show strong potential to become independent investigators in health-related research fields, supporting mentored research training. It is an individual award (not for organizations), and foreign organizations are listed as an other-eligible applicant category. No specific funding amount is given, and the deadline is not imminent.

National Institutes of Health · Amount varies

This NIH fellowship supports predoctoral students in combined MD/PhD or similar dual-doctoral degree programs at institutions that already have an NIH-funded dual-degree training program, preparing them for physician-scientist careers. It is limited to individual student applicants; foreign organizations and their non-U.S. components are not eligible, and applicants may not lead an independent clinical trial. No award amount is listed, and the deadline is not imminent.

National Institutes of Health · Amount varies

This NIH fellowship funds individual predoctoral students conducting dissertation research in health-related fields under a faculty sponsor, with the goal of developing them into independent researchers. It is limited to individual applicants (not organizations); foreign organizations are named as an other-eligible category, and applicants may not lead an independent clinical trial. No specific award amount is listed, and the deadline is several years out.

National Institutes of Health · Up to $200K

This NIH R25 supports short courses that teach innovative research methods in the behavioral and social sciences, aimed at developing the biomedical research workforce. Eligible applicants are research institutions such as universities and minority- or tribal-serving colleges, with foreign organizations excluded. Awards go up to $200,000.

National Institutes of Health · Amount varies

This NIH R34 funds early-stage research and pilot studies testing interventions to improve health outcomes in Native American communities, including etiologic research and culturally-informed treatment studies. Eligible applicants include universities, tribal colleges, minority-serving institutions, and community organizations, with some restrictions on foreign entities. No award amount is specified; a clinical trial component is optional.

National Institutes of Health · Up to $375K

NIH HEAL Initiative R15 funding for basic or mechanistic pain research at institutions eligible for the R15 (Research Enhancement) mechanism, which targets schools and components that have not been major NIH recipients. Aimed at engaging undergraduate, graduate, and health-professional trainees in the research; foreign organizations are not eligible. The listed maximum is about $375,000. R15 eligibility rules restrict which institutions can apply, so eligibility is narrow.

National Institutes of Health · Amount varies

Open to domestic institutions — universities, research institutions, nonprofits, and certain government/tribal organizations (foreign institutions are not eligible). This NIH T35 funds short-term (often summer) research-training experiences for health-professional and graduate students. It supports the institution's training program rather than an individual.

National Institutes of Health · Amount varies

The NIH parent Exploratory/Developmental Research Grant (R21, clinical trial required) supports early-stage research projects with at least one clinical trial, aligned with participating NIH institutes' missions. A broad range of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. No specific award amount is stated. The clinical-trial requirement makes this best suited to research institutions with trial capacity.

National Institutes of Health · Amount varies

The NIH parent Research Project Grant (R01, clinical trial required) supports investigator-initiated research projects, with at least one clinical trial required, aligned with participating NIH institutes' missions. A broad range of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. No specific award amount is stated. The clinical-trial requirement makes this best suited to research institutions with trial capacity.

National Institutes of Health · Amount varies

The NIH parent Exploratory/Developmental Research Grant (R21, clinical trial not allowed) supports early-stage, higher-risk research projects that may lead to breakthroughs or novel methods. A broad range of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. No specific award amount is stated. This is an exploratory research mechanism aimed at research institutions.

National Institutes of Health · Amount varies

The NIH parent Research Project Grant (R01, clinical trial not allowed) supports investigator-initiated research projects aligned with participating NIH institutes' missions, excluding clinical trials. A broad range of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. No specific award amount is stated. This is a core NIH research mechanism aimed at research institutions.

National Institutes of Health · Up to $375K

The REAP program funds small-scale research at health professional and graduate schools that haven't been major recipients of NIH support, while giving students hands-on research experience. Eligibility is limited to institutions awarding NIH-relevant degrees that received under $6 million per year in NIH support in 4 of the last 7 years — a specific financial threshold worth checking before applying. Awards go up to $375,000.

National Institutes of Health · Up to $1.1M

NIH (NCCIH) R33 funding for early-phase clinical trials of natural products (botanicals, dietary supplements, probiotics) to confirm target engagement and inform whether further clinical research is warranted. Intended for research institutions; foreign organizations are not eligible. The listed maximum is about $1,050,000. It will not support efficacy or effectiveness trials and requires strong preliminary data, making it narrow research-only funding.

National Institutes of Health · Up to $375K

An NIH Academic Research Enhancement Award (AREA/R15) for undergraduate-focused institutions that do not receive substantial NIH funding, supporting small-scale biomedical research with undergraduate involvement. Eligibility is narrow: institutions must award baccalaureate science degrees and have received no more than about $6 million per year of NIH support in 4 of the last 7 years; foreign organizations are not eligible. The award is capped at about $375,000. This is restricted to qualifying lower-NIH-funded undergraduate institutions.

National Institutes of Health · Amount varies

NIH (NCCIH) R01 funding for mid-phase clinical trials of natural products such as botanicals, dietary supplements, and probiotics that already have strong preliminary data. Intended for research institutions able to conduct hypothesis-driven, milestone-based clinical trials; foreign organizations are not eligible. No dollar amount is stated. It will not support efficacy/effectiveness trials or cancer-treatment trials, and requires substantial prior preliminary data, so it is narrow in scope.

National Institutes of Health · Up to $350K

NIH (NCCIH) phased R61/R33 funding for early-phase clinical trials of natural products (botanicals, probiotics, marketed dietary supplements) with a strong scientific rationale. Suited to research institutions running milestone-driven pharmacokinetic and target-engagement studies; foreign organizations are not eligible. The listed maximum is about $350,000. It is narrow research-only work requiring strong preliminary justification, not a fit for individuals or general nonprofits.

National Institutes of Health · Amount varies

This NIH R01 funds investigator-initiated, fully remote clinical trials testing complementary and integrative health interventions (with no in-person contact and possible mHealth tools) in NCCIH's priority research areas. Applicants must justify the remote approach and provide feasibility and safety preliminary data. It's aimed at eligible U.S. research institutions, and the deadline is November 17, 2026.

National Institutes of Health · Up to $350K

NIH (NCCIH) R01 funding for multi-site feasibility clinical trials of mind-and-body interventions to prepare for a later full-scale efficacy trial. Intended for research institutions able to coordinate across multiple sites; foreign organizations are not eligible (foreign components allowed). The listed maximum is about $350,000. Sufficient preliminary data from prior single-site work is required, making this narrowly scoped research funding.

National Institutes of Health · Amount varies

This NIH R34 grant funds feasibility trials of mind-and-body complementary health interventions for NCCIH-designated high-priority conditions, generating data needed to plan a subsequent full-scale efficacy or effectiveness trial. Applicants are encouraged to consult NCCIH staff before applying, and it's aimed at eligible U.S. research institutions. The deadline is November 17, 2026.

National Institutes of Health · Amount varies

This NIH training grant funds domestic institutions of higher education (including HBCUs, Hispanic-serving institutions, and tribal colleges) to build predoctoral and postdoctoral biomedical research training programs, not individual researchers directly. Eligibility is fairly broad among institution types, but non-domestic entities and their foreign components are excluded, and the program does not support short-term-only training plans. No dollar amount is listed, and the deadline is not near-term.

National Institutes of Health · Amount varies

An NIH BRAIN Initiative R01 funding the development and validation of novel tools to study cell-type- and circuit-specific processes in the brain. Eligibility is geared toward research institutions, including HBCUs, Hispanic-serving and Tribal colleges, and foreign organizations; this is a federal research grant, not a fit for typical nonprofits, small businesses, or individuals without an academic/research affiliation. No award amount is specified. Clinical trials are not allowed under this opportunity.

National Institutes of Health · Amount varies

This NIH R21 funds exploratory research on dissemination and implementation strategies for evidence-based health interventions, including studies on de-implementing low-value practices. Eligible applicants include universities and similar research institutions across NIH's mission areas. No award amount is specified.

National Institutes of Health · Amount varies

This NIH (R61/R33) phased opportunity funds mechanistic research to advance precision probiotic therapies, beginning with an exploratory phase to identify person-specific factors and a second phase to test them in animal models or human subjects, over a combined period of up to five years. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Transition between phases depends on meeting milestones. It is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R33) opportunity funds mechanistic research to advance precision probiotic therapies by characterizing person-specific factors that affect probiotic responses, using animal models or human subjects. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It expects supportive preliminary data and is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Up to $500K

An NIH UC2 program helping resource-limited organizations build biomedical research capacity and sponsored-programs administration. Eligible applicants include minority-serving and Tribal colleges and other domestic organizations with limited research resources; foreign organizations are not eligible. Awards reach up to about $500,000. This targets emerging or under-resourced research institutions rather than general nonprofits, small businesses, or individuals.

National Institutes of Health · Amount varies

This NIH R01 funds research identifying and testing strategies to help evidence-based health interventions get adopted, scaled, and sustained — or, conversely, to phase out ineffective practices. Eligible applicants include universities, minority- and tribal-serving institutions, and similar research organizations across NIH's mission areas. No award amount is specified.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative (U01) program funds development of next-generation sensors and bioelectronic devices that synchronize with brain recordings to build computational models of human and animal behavior. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research and technology-development teams, not individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH program supports preclinical discovery and development of biologic-based therapies for nervous system disorders, from lead optimization through Phase I clinical testing. Eligible applicants are research organizations such as universities, colleges, government and tribal agencies, faith- or community-based organizations, and (for this announcement) foreign organizations; it is geared toward established research teams, not individuals or general nonprofits. Award amounts are not specified. Applicants should be prepared for a complex, multi-phase research undertaking with NIH-funded consultants and contract research organizations.

National Institutes of Health · Amount varies

This NIH (R13) program supports conferences and scientific meetings relevant to public health and the missions of participating NIH institutes. Eligible applicants are U.S. research and education organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Note that R13 conference support typically requires advance permission from the funding institute before applying. It is aimed at organizations hosting scientific conferences, not individuals. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative (U24) program funds establishment of facilities at minority-serving institutions and IDeA-eligible institutions to produce and distribute brain cell type-specific research reagents to the neuroscience community. Eligibility is narrowed to minority-serving and IDeA-eligible U.S. institutions; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It is intended for qualifying research institutions, not individuals or general nonprofits, and awardees must coordinate with existing Armamentarium project teams. Award amounts are not specified.

National Institutes of Health · Up to $350K

This NIH HEAL Initiative R61/R33 funds early translational drug-discovery research toward non-addictive pain therapeutics, including assay development, screening, and initial characterization of candidate agents; no clinical trial is allowed. Eligible applicants include universities, research institutions, and tribal and community organizations, but foreign organizations are not eligible to apply. The maximum award is about $350,000. It requires drug-discovery research capacity.

National Institutes of Health · Amount varies

This NIH R50 award provides salary support for established Research Software Engineers who build and disseminate biomedical software, tools, and algorithms. Eligible applicants include universities and research institutions; foreign (non-U.S.) organizations are not eligible to apply. It is tied to an existing research environment and specialized staff, so it suits research institutions rather than general nonprofits or individuals applying on their own. No specific award amount is stated.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific NIH grants and need to transfer an award due to a change in organizational status (successor-in-interest). It is an administrative prior-approval request, not a new funding opportunity, and approval of the transfer is not guaranteed. Only current NIH grantee organizations should use it; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific types of NIH grants and need to transfer an existing award to a new recipient institution (a change of recipient organization). It is an administrative prior-approval request, not a new funding opportunity, and there is no guarantee a transfer will be approved. Only current NIH grantee organizations should apply; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH midcareer award (K24) provides protected time for mid-career clinician-scientists to conduct patient-oriented research and mentor junior clinical researchers; this version does not allow leading an independent clinical trial. It is intended for individual health-professional investigators applying through eligible institutions such as universities and academic medical centers. No award amount is listed.

National Institutes of Health · Amount varies

This NIH midcareer award (K24) provides protected time for mid-career clinician-scientists to conduct patient-oriented research and mentor junior clinical researchers, and this version requires an independent clinical trial. It is intended for individual health-professional investigators applying through eligible institutions such as universities and academic medical centers. No award amount is listed.

National Institutes of Health · Amount varies

This NIH mentored research scientist award (K01) provides three to five years of protected, supervised career development leading to research independence; this version does not allow leading an independent clinical trial. It is intended for individual investigators applying through eligible institutions such as universities. No award amount is listed.

National Institutes of Health · Amount varies

This NIH Pathway to Independence award (K99/R00) supports outstanding postdoctoral researchers transitioning to independent faculty positions; this version does not allow leading an independent clinical trial. It is intended for individual early-career investigators applying through eligible institutions such as universities; foreign organizations cannot apply. No award amount is listed.

National Institutes of Health · Amount varies

This NIH mentored career development award (K08) prepares individuals with a clinical doctoral degree for research careers through supervised biomedical, behavioral, or translational research; this version does not allow leading an independent clinical trial. It is intended for individual clinician-investigators applying through eligible institutions such as universities and academic medical centers. No award amount is listed.

National Institutes of Health · Amount varies

This NIH mentored research scientist award (K01) provides three to five years of protected, supervised career development in biomedical, behavioral, or clinical research leading to independence, and this version requires an independent clinical trial. It is intended for individual investigators applying through eligible institutions such as universities. No award amount is listed.

National Institutes of Health · Amount varies

This NIH mentored career development award (K08) prepares individuals with a clinical doctoral degree for research careers through supervised biomedical, behavioral, or translational research, and this version requires an independent clinical trial. It is intended for individual clinician-investigators applying through eligible institutions such as universities and academic medical centers. No award amount is listed.

National Institutes of Health · Amount varies

The NIH K99/R00 Pathway to Independence Award supports postdoctoral researchers transitioning to independent faculty positions, covering a mentored phase followed by several years of independent research funding. Applications are submitted through eligible research institutions — universities, minority-serving colleges, and similar organizations — on behalf of the individual awardee. No award amount is specified, and a clinical trial component is required for this version.

National Institutes of Health · Amount varies

This NIH mentored career development award (K23) supports individuals with a clinical doctoral degree committed to patient-oriented research, providing protected research time under mentorship, and this version requires an independent clinical trial. It is intended for individual clinician-investigators applying through eligible institutions such as universities and academic medical centers. No award amount is listed.

National Institutes of Health · Amount varies

This NIH mentored career development award (K23) supports individuals with a clinical doctoral degree who are committed to patient-oriented research, providing protected research time under mentorship. This version does not allow leading an independent clinical trial. It is intended for individual clinician-investigators applying through eligible institutions such as universities and academic medical centers. No award amount is listed.

National Institutes of Health · Up to $750K

An NIH BRAIN Initiative R18 funding preclinical proof-of-concept work on novel recording and modulation technologies for the human central nervous system, up to readiness for first-in-human studies. The eligibility text is mixed but states foreign organizations and foreign components are not eligible to apply, while domestic research institutions, minority-serving and Tribal colleges may. Awards reach up to about $750,000, and clinical trials are not allowed. This is a specialized research award, not a fit for general nonprofits, small businesses, or individuals.

National Institutes of Health · Amount varies

NIH mechanism allowing existing award recipients to apply for revision (supplemental) funding to expand a current NIH grant or cooperative agreement, only in response to a specific Notice of Special Interest. Restricted to organizations that already hold an active NIH single-project award. No award amount is specified. Because applicants must already be NIH grantees and respond to a matching NOSI, eligibility is narrow and not open to new applicants.