The Genesis Mission: Transforming Science and Energy with AI

Office of Science$500,000–$16,000,000Due Dec 17, 2026

Researchers Schools & universities Small business Large award Broad eligibility

Deadline: Dec 17, 2026
Posted: Mar 17, 2026
Award amount: $500,000–$16,000,000
Focus areas: Science and Technology and other Research and Development

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We’ll email you before Dec 17, 2026 so you have time to apply.

In plain English

The DOE Genesis Mission funds interdisciplinary teams using novel AI models to accelerate scientific discovery in areas like advanced manufacturing, biotechnology, critical materials, nuclear energy, quantum information, and semiconductors. Eligibility is broadly open to any entity type, subject to clarification in the RFA, with Phase I small-team and Phase II large-team awards. Awards are large, roughly $500,000 up to $16 million. It is aimed at research teams able to leverage national-laboratory, industry, and academic resources.

AI-generated summary to help you decide quickly — verify the official eligibility rules before applying.

Who can apply

Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

About this grant

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions). In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.

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