Mathematical and Physical Sciences Grants (Assistance Listing 47.049)

U.S. National Science Foundation · Amount varies

This NSF PESOSE program supports turning open-source science and engineering research products into secure, sustainable ecosystems, and eligibility is broad: U.S.-based for-profit organizations (including small businesses), non-profit non-academic organizations, federal agencies and FFRDCs, state and local governments, U.S. institutions of higher education, and federally recognized Tribal Nations may apply. PIs generally must be U.S.-resident employees of the applicant; foreign organizations and overseas branch campuses are not eligible. No specific award amount is stated; the deadline is September 1, 2026.

U.S. National Science Foundation · From $50K

Only accredited two- and four-year U.S. institutions of higher education (including community colleges) may apply to this NSF National I-Corps Teams program, acting on behalf of their faculty; individuals, nonprofits, and businesses cannot apply directly. It funds NSF-supported researchers with entrepreneurial training, mentoring, and roughly $50,000 to assess the commercial potential of deep-technology inventions from foundational research. Multiple awards based on the same core technology generally are not supported, and international branch campuses require special justification.

U.S. National Science Foundation · $600K–$2M

NSF Translation to Practice (TTP) program funding the translation of research results toward real-world products, services, and partnerships. Eligibility is limited to US nonprofits/non-academic research organizations and US institutions of higher education, and the PI must hold a tenured/tenure-track or full-time research/teaching appointment; the TTP-E track additionally requires an active eligible NSF research award. Awards range from about $600,000 up to $2,000,000. Eligibility is narrow given the active-award and appointment requirements.

U.S. National Science Foundation · $200K–$700K

The NSF, in partnership with the German Research Foundation (DFG), offers this Lead Agency opportunity in Chemistry and Chemical Process and Transport Systems, letting U.S. and German researchers submit a single collaborative proposal under one review. Eligibility is limited to U.S.-based institutions of higher education (including community colleges) and non-profit, non-academic research organizations directly tied to research or education; for-profit firms and individuals are not eligible. Awards roughly range from $200,000 to $700,000 and require a German research partner. No deadline is posted.

U.S. National Science Foundation · Amount varies

This NSF INCLUDES program funds collaborative, national-scale efforts to broaden participation and build inclusive infrastructure in STEM, supporting pilots, consortia, alliances, network connectors, and conferences. Eligibility is relatively broad: for-profit organizations including small businesses, nonprofit non-academic organizations, state and local governments, institutions of higher education, and federally recognized tribal nations may apply. No specific award amounts are listed. This is a research and capacity-building opportunity open to a range of organizations, though not to individuals.

U.S. National Science Foundation · Amount varies

NSF Applied Mathematics program funding research in mathematics motivated by problems in science and engineering, from single-investigator to interdisciplinary team projects. Eligibility is described as unrestricted/open to any entity type subject to standard NSF rules, though in practice these awards generally go to research institutions and their investigators; confirm specifics in the full solicitation. No award amount is specified. Eligibility as stated is broad.

U.S. National Science Foundation · Amount varies

This NSF program (RUI and ROA) supports research by faculty at predominantly undergraduate institutions, helping build campus research capacity and integrate research with undergraduate education. Only accredited colleges and universities (including two-year community colleges) that have awarded 20 or fewer Ph.D./D.Sci. degrees in NSF-supported fields over the prior two academic years may submit; this is a restrictive institutional eligibility rule. Funding amounts and a fixed deadline are not listed, so contact the relevant NSF disciplinary program officer to confirm fit and timing.

U.S. National Science Foundation · Amount varies

This NSF program funds open-science work such as research data management, cyberinfrastructure, and scientific publication models that make research data findable, accessible, interoperable, and reusable. Eligibility is limited to U.S. institutions of higher education, non-profit non-academic research organizations, federally recognized tribal nations, and certain federal agencies and FFRDCs. No award amount is listed.

U.S. National Science Foundation · $50K–$1.2M

The NSF Security, Privacy, and Trust in Cyberspace (SaTC 2.0) program funds research on the security, privacy, and resilience of cyber systems, spanning technical and social dimensions. Proposals may only be submitted by U.S. institutions of higher education and non-profit, non-academic research organizations; PIs must hold qualifying academic or research appointments, and individuals at for-profit organizations or overseas branch campuses are not eligible. Awards range from about $50,000 to $1.2M. Eligibility is restricted to higher-education and nonprofit research organizations.

U.S. National Science Foundation · $4M–$20M

An NSF program funding mid-scale research infrastructure (instrumentation, cyberinfrastructure, large datasets, and design activities). Eligible applicants are U.S. higher-education institutions, certain nonprofit non-degree-granting research organizations with 501(c)(3) status, and qualifying consortia; for-profit and small businesses may only participate through subawards, not as lead applicants. Awards are large, roughly $4,000,000 to about $20,000,000. This is a major research-infrastructure award, not a fit for general nonprofits, small businesses as primary applicants, or individuals.

U.S. National Science Foundation · $2M–$3M

This NSF Research Traineeship (NRT) program funds universities to develop interdisciplinary STEM graduate training models in high-priority research areas. Only U.S. institutions of higher education may apply, and the PI must be a faculty member at the submitting institution, so this is restricted to higher education. Awards range from roughly $2,000,000 to $3,000,000. Individuals, nonprofits, and businesses are not eligible to apply directly.

U.S. National Science Foundation · Amount varies

The NSF Computational and Data-Enabled Science and Engineering (CDS&E) meta-program funds research that uses new computational and data-analysis approaches to drive breakthroughs across science and engineering disciplines. Eligibility is unrestricted, so universities, research organizations, and other entity types may apply, though proposals must have a significant computational or data-science component beyond typical methods. No specific award amount or deadline is listed.

U.S. National Science Foundation · Amount varies

This NSF program funds quantum testbeds within the National Quantum Virtual Laboratory, advancing use-inspired quantum information science and technology. Eligibility for the Design and Implementation phases is contingent on having an existing pilot or design project in the same topical area and a positive site-visit review, so it is staged and not open to first-time entry at those phases; the lead organization type is otherwise unrestricted. No award amount is listed.

U.S. National Science Foundation · $1M–$1.5M

An NSF EPSCoR program funding interjurisdictional research collaborations in STEM, open to higher-education institutions, certain nonprofit research organizations with 501(c)(3) status, and Tribal governments located in EPSCoR-eligible jurisdictions. Applicants and investigators must be in EPSCoR jurisdictions and projects must span at least two such jurisdictions, which is a significant geographic restriction. Awards run roughly $1,000,000 to $1,500,000. Not a fit for organizations outside EPSCoR-eligible jurisdictions or without a research mission.

U.S. National Science Foundation · $500K–$1.5M

This NSF program funds research collaborations on the mathematical and theoretical foundations of AI and machine learning. Proposals may only be submitted by U.S. institutions of higher education (including community colleges) and U.S. non-profit, non-academic research organizations such as independent research laboratories and professional societies. The PI must hold a tenured/tenure-track position or a full-time paid research or teaching appointment; individuals at for-profit organizations or overseas branch campuses are not eligible. Awards range from about $500,000 to $1,500,000.

U.S. National Science Foundation · $50K–$600K

This NSF program funds early-stage collaborative projects that build research data infrastructure supporting public access and open science, bringing together cyberinfrastructure researchers, data and library experts, and research labs. Eligibility is unrestricted, so most entity types may apply, though successful projects rely on cross-disciplinary teams typically based at universities and research organizations; proposals are accepted year-round. Awards range from about $50,000 to $600,000.

U.S. National Science Foundation · Amount varies

This NSF Probability Program supports research on the theory and applications of probability, including stochastic processes and related areas, as well as conference and workshop proposals. Eligibility is stated as unrestricted (open to any eligible entity type), so review the solicitation for the specific organization categories NSF allows. In practice NSF research grants are awarded to institutions on behalf of investigators rather than to individuals. Award amounts are not specified here.

U.S. National Science Foundation · Up to $200K

NSF's EPSCoR Workshop Opportunities program funds workshops (up to $200,000) addressing multi-jurisdictional research themes, but only for institutions of higher education, eligible nonprofits, or federally recognized tribal nations located within designated EPSCoR-eligible states and territories. Organizations outside EPSCoR-eligible jurisdictions do not qualify, making this a geographically restricted opportunity.

U.S. National Science Foundation · Amount varies

This NSF EPSCoR program funds research fellowships that build research capacity for investigators in EPSCoR-eligible jurisdictions through collaborative visits to host institutions. Eligibility is restricted to organizations located in RII-eligible jurisdictions, and proposals are limited to single early- or mid-career PIs at eligible institutions of higher education or non-degree-granting nonprofits with 501(c)(3) status; postdocs in transitional appointments are not eligible. No award amount is listed.

U.S. National Science Foundation · $1.2M–$3.6M

An NSF program funding interdisciplinary convergence research teams tackling complex scientific or societal problems. Eligible applicants are U.S. higher-education institutions and certain nonprofit non-academic research/education organizations, with principal investigators required to hold full-time research or teaching appointments. Awards are large, roughly $1,200,000 to $3,600,000. This targets academic research teams, not general nonprofits, small businesses, or individuals.

U.S. National Science Foundation · Amount varies

NSF Plasma Physics program funding research on plasmas across applications from astrophysics to fusion and materials science, generally submitted through the Division of Physics investigator-initiated solicitation. Eligibility is described as unrestricted/open to any entity type subject to standard NSF rules, though awards generally go to research institutions and investigators; confirm in the full solicitation. No award amount is specified. Eligibility as stated is broad.

U.S. National Science Foundation · Amount varies

NSF's Windows on the Universe multi-messenger astrophysics (WoU-MMA) program supports research coordinating, observing, or interpreting astrophysical sources across electromagnetic waves, high-energy particles, and gravitational waves. Eligibility is described as unrestricted (open to any entity type), subject to clarifications in the solicitation. No specific award amount is stated. Proposals should be directed to the relevant participating NSF programs.

U.S. National Science Foundation · Amount varies

Open to U.S. nonprofit research organizations (museums, observatories, labs, professional societies) and accredited two- and four-year higher-education institutions submitting on behalf of faculty; individual researchers cannot apply directly. Funds fundamental materials science research spanning nanoscale to macroscale phenomena, materials discovery, and characterization. International branch campuses face extra justification requirements, and no award amount or deadline is listed in this posting.

U.S. National Science Foundation · Amount varies

The NSF Condensed Matter and Materials Theory (CMMT) program funds fundamental theoretical and computational research on hard and soft materials and materials phenomena, including data-centric and machine-learning approaches. Eligible applicants are limited to U.S. institutions of higher education and U.S. non-profit, non-academic research organizations such as museums and research laboratories; for-profit firms and individuals cannot submit. No specific award amount or deadline is listed, and there are limits on the number of proposals per principal investigator.

U.S. National Science Foundation · $1.5M–$6.5M

This National Science Foundation program funds Mathematical Sciences Research Institutes as national resources that advance research in mathematics and statistics and broaden participation, with awards ranging roughly from $1.5 million to $6.5 million. Only U.S.-based non-profit non-academic research organizations and accredited institutions of higher education may apply; multi-institutional consortia are allowed but one entity must take overall management responsibility. Individuals and for-profit firms are not eligible.

U.S. National Science Foundation · From $190K

These NSF Mathematical Sciences Postdoctoral Research Fellowships are awarded to individuals, who submit proposals directly to NSF rather than through an institution, though fellows must affiliate with a host institution. Applicants must be U.S. citizens, nationals, or permanent residents, have a doctoral degree (conferred no more than two years before January 1 of the award year), propose research in mathematics or statistics, and not have previously held most NSF awards. Eligibility is therefore narrow and individual-specific. Stated funding is around $190,000.

U.S. National Science Foundation · Amount varies

This NSF program (HBCU Excellence in Research) is restricted to accredited Historically Black Colleges and Universities that have faculty conducting research in science, engineering, or STEM education. The PI must be a full-time faculty member or researcher at the submitting HBCU, so no other organization type is eligible. It aims to build research capacity at HBCUs, particularly those less successful in larger NSF competitions. No specific award amount is stated in this record.

U.S. National Science Foundation · Amount varies

The NSF Division of Chemistry funds disciplinary research across six chemistry programs (catalysis, measurement and imaging, mechanism, synthesis, environmental chemistry, and nanochemistry). Proposals may only be submitted by U.S. institutions of higher education and non-profit, non-academic research organizations such as museums, observatories, and research labs; this is not open to individuals or most businesses. No award amount is stated. Higher-ed and research-institution focus makes eligibility relatively narrow.

U.S. National Science Foundation · $100K–$4M

NSF Major Research Instrumentation program funding the acquisition or development of multi-user research instruments. Eligibility is limited to US institutions of higher education and US not-for-profit, non-degree-granting research organizations with 501(c)(3) status; for-profit firms can participate only as subaward partners and cannot apply directly. Awards range from about $100,000 up to $4,000,000. This is narrowly scoped to research institutions and large in size.

U.S. National Science Foundation · Up to $1M

An NSF program funding training, education, and curriculum development to grow the workforce for advanced cyberinfrastructure and computational/data-driven research. Proposals must include a principal investigator or co-PI with expertise relevant to NSF's Office of Advanced Cyberinfrastructure, and the program is oriented toward research and education institutions. Awards reach up to about $1,000,000. This is a research/education-workforce grant, not a fit for general nonprofits, small businesses, or individuals.

U.S. National Science Foundation · Amount varies

NSF program (ATI) funding the development of new technologies and instrumentation for ground-based astronomy and astrophysics, including high-risk concepts, hardware, and software. Eligibility is described as unrestricted/open to any entity type subject to standard NSF rules, though awards generally go to research institutions and investigators; confirm in the full solicitation. No award amount is specified. Eligibility as stated is broad.

U.S. National Science Foundation · Amount varies

NSF Astronomy and Astrophysics Research Grants program funding observational, theoretical, laboratory, and archival studies in astronomy and astrophysics, for individual investigators or collaborations. Eligibility is described as unrestricted/open to any entity type subject to standard NSF rules, though awards generally go to research institutions and investigators; confirm in the full solicitation. No award amount is specified. Eligibility as stated is broad.

U.S. National Science Foundation · From $110K

These NSF Astronomy and Astrophysics Postdoctoral Fellowships are awarded to individuals, who submit directly to NSF and must identify a scientific mentor and eligible host institution at the time of application. Applicants must be U.S. citizens, nationals, or lawful permanent residents and must have earned (or be about to earn) a doctorate within five years of the deadline. Host institutions are limited to U.S. universities, NSF-funded centers, and certain U.S. non-profits; centers funded by other agencies such as NASA or DOE are ineligible. Stated funding is around $110,000.

U.S. National Science Foundation · Amount varies

This NSF Mathematical Biology program supports research across the mathematical sciences with relevance to biology, requiring strong integration of mathematical innovation and biological significance. Eligibility is described as unrestricted (open to any standard NSF entity type) subject to clarification in the NOFO, so a broad range of research organizations such as universities may apply; in practice proposals are typically led by institutions of higher education. The program also supports conferences and special proposal types (EAGER, RAPID, RUI). No specific award amount is stated in this record.

U.S. National Science Foundation · Amount varies

The NSF Division of Chemistry is piloting no-deadline submission for its Chemistry of Life Processes, Chemical Structure and Dynamics, and Chemical Theory/Computational Methods programs. Eligibility is limited to U.S.-based nonprofit non-academic research organizations (such as independent museums, observatories, and research labs) and accredited U.S. institutions of higher education acting for their faculty; individuals and businesses do not qualify. No specific award amount is listed, and proposals may be submitted at any time.

U.S. National Science Foundation · $1–$1.2M

This joint NSF/NIH initiative funds fundamental mathematics and statistics research aimed at answering questions in the biological and biomedical sciences, with two tracks supporting projects up to roughly $600,000 or $1,200,000 over 3-4 years. Eligibility is stated as unrestricted (open to any eligible entity type), so review the solicitation for the specific organization categories allowed; in practice NSF awards go to institutions on behalf of investigators. The program encourages new and existing interdisciplinary collaborations. Award amounts can reach the large-award range.

U.S. National Science Foundation · Amount varies

This NSF program funds research in topology, including algebraic and geometric topology, homotopy theory, knots, and topological data analysis, plus conferences and travel. Eligibility is described as unrestricted, open to the broad range of NSF-eligible entities (typically universities, nonprofits, and similar research organizations), subject to additional clarifications. No specific award amounts are listed, though conference proposals reference budgets around $50,000. This is a research-focused opportunity; whether a given applicant qualifies depends on standard NSF eligibility, which the notice does not fully detail here.

U.S. National Science Foundation · Amount varies

This NSF program funds research in geometric analysis, including differential geometry, geometric group theory, geometric data analysis, and related mathematical topics, plus conferences and travel. Eligibility is described as unrestricted, open to the broad range of NSF-eligible entities (typically universities, nonprofits, and similar research organizations), subject to additional clarifications. No specific award amounts are listed, though conference proposals reference budgets around $50,000. This is a research-focused opportunity; whether a given applicant qualifies depends on standard NSF eligibility, which the notice does not fully spell out here.

U.S. National Science Foundation · Amount varies

This NSF Algebra and Number Theory program supports research in algebra, algebraic and arithmetic geometry, number theory, and representation theory, and also funds conferences, workshops, and summer/winter schools. Eligibility is described as unrestricted (open to any standard NSF entity type), subject to clarification in the NOFO, though proposals are typically led by universities and research organizations. Conference proposals follow specific submission windows depending on budget size. No specific award amount is stated in this record.

U.S. National Science Foundation · Amount varies

NSF's Analysis Program supports mathematical research in areas such as complex, harmonic, and real analysis, dynamical systems, functional analysis, mathematical physics, operator theory, and partial differential equations. Eligibility is described as unrestricted (open to any entity type), subject to clarifications in the solicitation. No specific award amount is stated. Conference and workshop proposals must be submitted through a separate NSF solicitation rather than this program.

U.S. National Science Foundation · Amount varies

Eligibility is unrestricted (open to any entity type, subject to NSF clarifications), but this National Science Foundation program funds crosscutting materials-research activities such as diversity and inclusion efforts, international cooperation, education, workshops, summer schools, and conferences rather than traditional research projects. Award amounts and deadlines are not specified, and program directors recommend contacting them before submitting any full proposal exceeding $50,000. Foreign organizations face the usual NSF limitations, so most awards go to U.S. institutions.

U.S. National Science Foundation · Amount varies

The NSF Statistics program supports research in statistical theory and methods, including methods applicable across science and engineering, from single-investigator to interdisciplinary team projects. Eligibility is broadly open to the entity types NSF generally accepts, subject to any additional clarification in the solicitation. It is aimed at researchers and academic institutions. No specific award amount is stated.

U.S. National Science Foundation · Amount varies

The NSF Foundations program supports research in mathematical logic and the foundations of mathematics, including proof theory, recursion theory, model theory, set theory, and combinatorics, and can also support conferences and workshops. Eligibility is described as unrestricted (open to any eligible entity type), subject to any clarifications in the solicitation, though NSF awards generally go to institutions and research organizations rather than individuals directly. No award amount is stated. Review the full solicitation for any eligibility clarifications.

U.S. National Science Foundation · Amount varies

The NSF Combinatorics program supports research on discrete structures, including algebraic, enumerative, extremal, geometric, and probabilistic combinatorics and graph theory, and can support related conferences and workshops. Eligibility is described as unrestricted (open to any eligible entity type), subject to clarifications in the solicitation, though NSF funding typically flows to institutions and research organizations. No award amount is stated. Review the full solicitation for eligibility details and conference submission timelines.

U.S. National Science Foundation · $1–$1.2M

NSF Computational Mathematics program funding research where computation is central, emphasizing development and implementation of efficient, theoretically justified algorithms. Eligibility is described as unrestricted/open to any entity type subject to standard NSF rules, though awards typically go to research institutions and their investigators; confirm in the full solicitation. The listed maximum is about $1,200,000. Eligibility as stated is broad.

U.S. National Science Foundation · Amount varies

NSF's National Facilities program funds operation of specialized national research facilities (for example, high magnetic field, x-ray/synchrotron, neutron scattering, and nanofabrication facilities) serving the broader scientific community. Eligibility is unrestricted among standard NSF applicant types, but in practice this suits large research institutions capable of operating major shared facilities rather than typical small nonprofits or businesses. No specific award amount is listed.