Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)
An NIH U01 supporting collaborative translational research conducted with NIH intramural investigators using the NIH Clinical Center. Domestic and foreign organizations may apply, but NIH will not …
- Deadline
- Mar 6, 2027
- Posted
- Dec 8, 2025
- Award amount
- Up to $500,000
- Focus areas
- Health
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We’ll email you before Mar 6, 2027 so you have time to apply.
In plain English
An NIH U01 supporting collaborative translational research conducted with NIH intramural investigators using the NIH Clinical Center. Domestic and foreign organizations may apply, but NIH will not fund awards involving foreign subawards/subcontracts under this opportunity, so applications relying on foreign subawards are excluded. Awards reach up to about $500,000. This is a research grant for investigators able to partner with NIH, not for general nonprofits, small businesses, or individuals.
AI-generated summary to help you decide quickly — verify the official eligibility rules before applying.
Who can apply
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
About this grant
The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs).Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance translational science by promoting partnerships between NIH intramural investigators (e.g., those conducting research within the labs and clinics of the NIH) and extramural investigators (e.g., those conducting research in labs outside the NIH), and by providing support for extramural investigators to take advantage of the unique research opportunities available at the NIH Clinical Center by conducting clinical research projects in collaboration with NIH intramural investigators.
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