Grants for State, Local & Tribal Governments

Bureau of Reclamation · $1K–$120M

This Bureau of Reclamation program funds planning, design, and construction of seawater or brackish-water desalination facilities, with awards reported up to about $120 million. Eligible applicants are states and their subdivisions and public agencies such as tribes, municipalities, irrigation, water, and wastewater districts, and all applicants must be located in one of 17 named Western states. Federal entities, foreign entities, individuals, and institutions of higher education are not eligible. WaterSMART construction projects typically require a substantial non-federal cost share, so confirm the cost-share terms in the full announcement; this is a large-award, geographically restricted program for public water agencies.

Bureau of Reclamation · $1K–$40M

This Bureau of Reclamation Title XVI program funds planning, design, and construction of water reclamation and reuse projects, with awards reported up to about $40 million. Eligible applicants are state, regional, or local authorities such as states, tribes, municipalities, irrigation, water, and wastewater districts, and other water/power delivery organizations located in named Western states or territories; eligibility is further limited to sponsors of specific authorized Title XVI projects or projects qualifying under the WIIN Act. Federal entities, foreign entities, individuals, and institutions of higher education are not eligible. WaterSMART projects typically require a substantial non-federal cost share, so confirm terms in the full announcement; this is a large-award, narrowly restricted program for public water agencies.

National Institutes of Health · Amount varies

This NIH (R21) opportunity supports exploratory research in computational genomics, data science, statistics, and bioinformatics relevant to basic or clinical genomic science and human health. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is intended for established research teams rather than individuals or general nonprofits. Award amounts are not specified. Methods should be generalizable and scalable to large datasets.

National Institutes of Health · Amount varies

This NIH (R01) opportunity funds research in computational genomics, data science, statistics, and bioinformatics relevant to basic or clinical genomic science and broadly applicable to human health. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research teams rather than individuals or general nonprofits. Award amounts are not specified. Methods are expected to be generalizable and scalable to large datasets.

National Institutes of Health · Amount varies

This NIH (R21) opportunity supports exploratory community-engaged research to develop novel, culturally and linguistically responsive measures of children's language development and supportive environmental factors. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research teams rather than individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (U01) program funds academic-industry research partnerships that develop and advance bioengineering tools and technologies to address biomedical problems, aiming for solutions deployable within roughly 5-10 years. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is geared toward multidisciplinary research teams partnered with industry, not individuals or general nonprofits. Award amounts are not specified. Applicants should expect a collaborative, milestone-driven structure.

National Institutes of Health · Amount varies

This NIH (R01) opportunity funds non-pharmacological interventions to promote sleep health and reduce sleep-related health disparities among populations that experience health disparities. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply. It is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R13) program supports conferences and scientific meetings relevant to public health and the missions of participating NIH institutes. Eligible applicants are U.S. research and education organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Note that R13 conference support typically requires advance permission from the funding institute before applying. It is aimed at organizations hosting scientific conferences, not individuals. Award amounts are not specified.

National Institutes of Health · Up to $100K

This NIH (NIDA, R03) award helps investigators enter addiction-related data science, supporting small-scale projects that apply emerging data science methods or generate preliminary data for larger studies, with a budget cap around $100,000. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is intended for investigators at research institutions, not individuals or general nonprofits. It encourages use of existing datasets and FAIR principles. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (R01) opportunity funds community-engaged research to develop novel, culturally and linguistically responsive measures of children's language development and the environmental factors that support it. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is intended for established research teams rather than individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

Bureau of Reclamation · $50K–$3M

This Bureau of Reclamation program funds water resource projects such as conservation and efficiency, infrastructure improvements, and watershed restoration, with awards from about $50,000 up to $3 million. Eligible applicants are states, tribes, irrigation and water districts, water/power authorities, certain nonprofit conservation organizations partnering with those entities, and qualifying watershed groups; applicants generally must be in the Western U.S. or named territories. Federal entities, individuals, and institutions of higher education are not eligible, and projects require a cost share (typically 25-50 percent of total cost). This is a geographically restricted opportunity aimed at water-management organizations.

National Institutes of Health · Amount varies

This NIH (NCI, U01) program funds research on how preanalytical variability in handling tumor tissue, blood, and other biospecimens affects clinically relevant biomarkers, to support standardization of biopsy handling and clinical assay development. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research teams, not individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (NICHD, P41) program supports continued operation, maintenance, and dissemination of bioinformatics database resources important to research using animal models of embryonic development. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components of U.S. organizations are not eligible. It is intended for institutions that operate established bioinformatics resources, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (NCATS, UM1) program funds Clinical and Translational Science Award (CTSA) hubs that join a national consortium to accelerate translational research, training, and rapid public health response. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible, though some foreign components are allowed. It is aimed at major academic medical and research institutions capable of operating a CTSA hub, not individuals or general nonprofits. Award amounts are not specified but such hubs are typically large, multi-year awards.

Defense Health Agency Contracting Activity - DHACA · Amount varies

This Defense Health Agency broad agency announcement (BAA) solicits extramural basic and applied medical research and development proposals that benefit both military and civilian medical practice. Eligibility is unrestricted, meaning any type of entity may apply, subject to clarifications in the notice. No award amount is specified. The selection process is highly competitive, and projects must focus on advancing scientific knowledge rather than developing a specific system or product.

Air Force -- Research Lab · Amount varies

This Air Force Research Laboratory solicitation (CHEERS) seeks white papers, and potentially later proposals, on human-effectiveness and aerospace-medicine research for experimental and test purposes in defense development. Eligibility is unrestricted, meaning any type of entity may apply, subject to clarifications in the notice. No award amount is specified. Applicants must reference the related Multiple Authority Announcement to obtain required attachments, and the work is tied to specific defense research objectives.

National Institutes of Health · Amount varies

This NIH/NCI U01 funds cancer etiology and early-detection biomarker research that must use the NCI-sponsored PLCO Screening Trial biospecimen resource. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it targets research organizations, not individuals. No award amount is specified. Projects that do not use PLCO biospecimens will not be funded, which narrows eligibility significantly.

National Institutes of Health · Amount varies

This NIH/NINDS U01 funds IND-enabling studies and planning for first-in-human testing of gene-based therapies for ultra-rare neurological and neuromuscular disorders. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; foreign organizations are not eligible, and it targets research organizations rather than individuals. No award amount is specified. The ultra-rare gene-therapy focus makes eligibility narrow.

National Institutes of Health · Up to $500K

This NIH/NIDCD R01 funds translational research that turns basic findings into clinical tools for communication disorders such as hearing, balance, voice, speech, and language. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations, not individuals. Awards reach up to about $500,000. Projects must show a clear clinical connection and practical impact, so the scope is specific.

National Institutes of Health · Amount varies

This NIH/NIMH award (R61/R33) funds feasibility work followed by clinical trials testing mental-health system interventions to improve the organization, delivery, and outcomes of mental health services. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations rather than individuals. No award amount is specified. The focus on system-level interventions and required clinical trial make the scope narrow.