Grants for State, Local & Tribal Governments

U.S. National Science Foundation · Amount varies

This NSF solicitation funds Antarctic research that requires logistical fieldwork support from the U.S. Antarctic Program (USAP), spanning Earth systems, biological, geochemical, and physical sciences. Eligible applicants are limited to U.S.-based non-profit non-academic research organizations (such as museums, observatories, and research laboratories), accredited U.S. institutions of higher education, and federally recognized tribal nations; individuals and businesses are not among the listed eligible submitters. Available USAP logistical support is currently limited due to facility maintenance, so applicants should follow the solicitation's guidance. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R33) opportunity funds mechanistic research to advance precision probiotic therapies by characterizing person-specific factors that affect probiotic responses, using animal models or human subjects. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It expects supportive preliminary data and is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R61/R33) phased opportunity funds mechanistic research to advance precision probiotic therapies, beginning with an exploratory phase to identify person-specific factors and a second phase to test them in animal models or human subjects, over a combined period of up to five years. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Transition between phases depends on meeting milestones. It is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

Department of Housing and Urban Development · $0

This HUD notice of intent previews a future opportunity inviting unsolicited research proposals on housing and community development priorities such as affordability, homelessness, and housing stability. Eligible applicants are philanthropic entities (including 501(c)(3) foundations and public charities), other federal agencies, state or local governments, Indian tribes, tribally-designated housing entities, and colleges or universities; individuals, foreign entities, and sole proprietorships are not eligible, and no profit may be earned. Note a significant disqualifier: projects must include matching funds equal to at least 50 percent of total project cost. Award amounts are not specified in the notice.

National Institutes of Health · Amount varies

Open to domestic research organizations including universities, minority-serving institutions, tribal governments, and faith- and community-based groups under this NIGMS R24 resource award; foreign organizations and foreign components are not eligible. Funds shared resources that give a regional (multi-state) or national user base access to state-of-the-art equipment, technologies, tools, materials, software, or services within NIGMS program areas, including web presence, outreach, and user training. Resources should already exist or be formed from existing facilities; no specific award amount is stated.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative (U01) program funds development of next-generation sensors and bioelectronic devices that synchronize with brain recordings to build computational models of human and animal behavior. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research and technology-development teams, not individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (NIDCD, R21) opportunity is a planned re-issue to support early-stage dissemination and implementation research in hearing, balance, taste, smell, voice, speech, and language. For this announcement foreign organizations and non-U.S. components are eligible to apply, but NIH will not issue awards involving foreign subawards/subcontracts unless submitted under a specifically designated international-collaboration announcement. Note the announcement states applications are not being solicited at this time, so it is a notice of intent rather than an open call. It is intended for research institutions, not individuals or general nonprofits. Award amounts are not specified.

Department of Housing and Community Development · Amount varies

Open to public agencies in California (cities, counties, and similar local government entities) under this state Department of Housing and Community Development program. Funds the predevelopment, development, acquisition, rehabilitation, and preservation of affordable rental and ownership housing, accessory dwelling units, housing trust fund matches, and assistance for people experiencing or at risk of homelessness. No award amounts are listed, and homelessness activities must follow Housing First practices; nonprofits and individuals are not the named applicants.

National Institutes of Health · Amount varies

This NIH (R21) opportunity funds preclinical efficacy studies in established rare-disease models to demonstrate that a candidate therapeutic warrants further development, including supporting pharmacokinetic and pharmacodynamic studies. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It is intended for research teams advancing therapeutic candidates, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific types of NIH grants and need to transfer an existing award to a new recipient institution (a change of recipient organization). It is an administrative prior-approval request, not a new funding opportunity, and there is no guarantee a transfer will be approved. Only current NIH grantee organizations should apply; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific NIH grants and need to transfer an award due to a change in organizational status (successor-in-interest). It is an administrative prior-approval request, not a new funding opportunity, and approval of the transfer is not guaranteed. Only current NIH grantee organizations should use it; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Up to $150K

Open to a broad range of research organizations including universities, minority-serving institutions, tribal governments, faith- and community-based organizations, and foreign organizations under this NIDA R21 award (clinical trial optional). Funds highly innovative, high-risk basic research on the causes, prevention, or treatment of substance use disorders, including revolutionary methods or untested but transformative hypotheses. Awards are capped at roughly $150,000 in direct costs.

National Institutes of Health · Amount varies

This NIH program supports preclinical discovery and development of biologic-based therapies for nervous system disorders, from lead optimization through Phase I clinical testing. Eligible applicants are research organizations such as universities, colleges, government and tribal agencies, faith- or community-based organizations, and (for this announcement) foreign organizations; it is geared toward established research teams, not individuals or general nonprofits. Award amounts are not specified. Applicants should be prepared for a complex, multi-phase research undertaking with NIH-funded consultants and contract research organizations.

Bureau of Reclamation · $1K–$120M

This Bureau of Reclamation program funds planning, design, and construction of seawater or brackish-water desalination facilities, with awards reported up to about $120 million. Eligible applicants are states and their subdivisions and public agencies such as tribes, municipalities, irrigation, water, and wastewater districts, and all applicants must be located in one of 17 named Western states. Federal entities, foreign entities, individuals, and institutions of higher education are not eligible. WaterSMART construction projects typically require a substantial non-federal cost share, so confirm the cost-share terms in the full announcement; this is a large-award, geographically restricted program for public water agencies.

Bureau of Reclamation · $1K–$40M

This Bureau of Reclamation Title XVI program funds planning, design, and construction of water reclamation and reuse projects, with awards reported up to about $40 million. Eligible applicants are state, regional, or local authorities such as states, tribes, municipalities, irrigation, water, and wastewater districts, and other water/power delivery organizations located in named Western states or territories; eligibility is further limited to sponsors of specific authorized Title XVI projects or projects qualifying under the WIIN Act. Federal entities, foreign entities, individuals, and institutions of higher education are not eligible. WaterSMART projects typically require a substantial non-federal cost share, so confirm terms in the full announcement; this is a large-award, narrowly restricted program for public water agencies.

National Institutes of Health · Amount varies

This NIH (R01) opportunity funds community-engaged research to develop novel, culturally and linguistically responsive measures of children's language development and the environmental factors that support it. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is intended for established research teams rather than individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (R13) program supports conferences and scientific meetings relevant to public health and the missions of participating NIH institutes. Eligible applicants are U.S. research and education organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Note that R13 conference support typically requires advance permission from the funding institute before applying. It is aimed at organizations hosting scientific conferences, not individuals. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (U01) program funds academic-industry research partnerships that develop and advance bioengineering tools and technologies to address biomedical problems, aiming for solutions deployable within roughly 5-10 years. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is geared toward multidisciplinary research teams partnered with industry, not individuals or general nonprofits. Award amounts are not specified. Applicants should expect a collaborative, milestone-driven structure.

National Institutes of Health · Amount varies

This NIH (R21) opportunity supports exploratory community-engaged research to develop novel, culturally and linguistically responsive measures of children's language development and supportive environmental factors. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research teams rather than individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (R01) opportunity funds research in computational genomics, data science, statistics, and bioinformatics relevant to basic or clinical genomic science and broadly applicable to human health. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research teams rather than individuals or general nonprofits. Award amounts are not specified. Methods are expected to be generalizable and scalable to large datasets.