DoW Amyotrophic Lateral Sclerosis Research Program, Clinical Outcomes and Biomarkers Award

Defense Health Agency Contracting Activity - DHACAAmount not specifiedDue Sep 30, 2026

Researchers Schools & universities Broad eligibility

Deadline: Sep 30, 2026
Posted: May 4, 2026
Award amount: Amount not specified
Focus areas: Science and Technology and other Research and Development

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In plain English

This Department of War (Defense Health Agency) ALS Research Program Clinical Outcomes and Biomarkers Award supports development and validation of clinical outcomes and biomarkers to enrich ALS clinical trials. Eligibility is described as unrestricted (open to any entity type), subject to clarifications. Projects may target a specific therapy, therapeutic class, or ALS subtype and may use digital health measures. Community collaboration informed by the ALS lived-experience community is expected. No specific award amount is stated.

AI-generated summary to help you decide quickly — verify the official eligibility rules before applying.

Who can apply

Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

About this grant

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in amyotrophic lateral sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients. Distinctive Features: To meet the intent of the funding opportunity, applications may address clinical biomarkers and/or clinical outcomes . This may include the identification, development, and/or validation of promising biomarkers for ALS, which may include, but are not limited to susceptibility/risk, diagnostic, monitoring/disease progression, prognostic, predictive, response, or safety biomarkers. Clinical Outcomes projects may focus on the identification, development, and/or validation of clinician-, observer-, or patient-reported, and/or performance outcome measures for ALS. Projects may include the optimization of current outcome measures already in use. Applications may utilize digital health measures, including wearable devices, smart-phone sensors, video or voice recordings, imaging studies, or other devices which record disease-relevant physiological data and/or outcomes. Community Collaboration is an important element of the FY26 ALSRP COBA. Applicants will be expected to articulate how the proposed research question or study design was informed by the ALS lived experience community.

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