Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
An NIH R01 funding discovery and optimization of in vivo chemical probes for novel nervous-system targets, with applicants expected to already have validated starting compounds and bioassays in han…
- Deadline
- Mar 5, 2027
- Posted
- May 4, 2026
- Award amount
- Amount not specified
- Focus areas
- Health
Don’t miss this deadline
We’ll email you before Mar 5, 2027 so you have time to apply.
In plain English
An NIH R01 funding discovery and optimization of in vivo chemical probes for novel nervous-system targets, with applicants expected to already have validated starting compounds and bioassays in hand. Domestic and foreign organizations and foreign components are eligible to apply. No award amount is specified, and clinical trials are not allowed. This is a research grant for investigators with existing medicinal-chemistry capacity, not for general nonprofits, small businesses, or individuals.
AI-generated summary to help you decide quickly — verify the official eligibility rules before applying.
Who can apply
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
About this grant
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.
Let AI draft your application
Your first draft is free: a narrative and budget outline tailored to this grant, emailed to you. Drafts are written in a nightly batch, so it arrives by email later — not instantly on this page.
Application Kit — $49 one-time
Winner intelligence + a first-draft narrative grounded in applications that actually won. One payment, no subscription.
Get the Application Kit →Related grants
Other open grants funding Health — soonest deadline first.
Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)
National Institutes of Health · Amount varies · Due in 17 days
National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)
National Institutes of Health · Amount varies · Due in 17 days
Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed)
National Institutes of Health · Amount varies · Due in 17 days
Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)
National Institutes of Health · Amount varies · Due in 17 days
NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required)
National Institutes of Health · Amount varies · Due in 28 days
NCI Community Oncology Research Program (NCORP) Academic Community Sites (UG1 Clinical Trials Not Allowed)
National Institutes of Health · Amount varies · Due in 28 days
Also listed under National Institutes of Health and Health Grants.
Source: public records via Grants.gov. UseGrants is an independent aggregator, not affiliated with any funding agency. Always confirm details on the official listing before applying.